1. 当前位置：首页 > 研究队伍 > 副高级

雍天乔

                                                                   

食用菌研究发展中心    副研究员

研究领域：

 1. 开展食药用真菌次级代谢产物的快速分离、结构鉴定，以及生物活性评价，为创新药物研发提供先导化合物。

 2. 将药理学、化学、生物信息学和分子模拟紧密结合，开展传统食药用真菌调节尿酸代谢、糖脂代谢和神经代谢紊乱药效物质基础和作用机制研究，为食药用真菌精准营养提供小分子、多糖和蛋白等分子实体配料。 

 3. 致力于真菌次级代谢产物生物合成与调控机制研究，以合成生物学策略发现真菌活性分子、生物合成途径重建与调控及代谢途径设计。

获奖、荣誉及国内外学术团体任职情况：

  担任Journal of Agricultural and Food Chemistry, Food & Function等10多个SCI杂志特约审稿人。

代表论著：

1. Liang, D.; Yong, T. （通讯作者）; Diao, X.; Chen, S.; Chen, D.; Xiao, C.; Zuo, D.; Xie, Y.; Zhou, X.; Hu H. Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette superfamily G member 2. Pharm Biol 2021. doi:10.1080/13880209.2021.1885450 .

2. Liu, T.T.; Ye, F.C.; Pang, C.P.; Yong, T.Q.; Tang, W.D.; Xiao, J.; Shang, C.H.; Lu, Z.J. Isolation and identification of bioactive substance 1-hydroxyphenazine from Pseudomonas aeruginosa and its antimicrobial activity. Letters in Applied Microbiology 2020, 71: 303-310.

3. Yong, T.; Chen, S.; Liang, D.; Zuo, D.; Diao, X.; Deng, C.; Wu, Y.; Hu, H.; Xie, Y.; Chen, D. Actions of Inonotus obliquus against hyperuricemia through XOD and bioactives screened by molecular modeling. Int J Mol Sci 2018, 19, 3222.

4. Yong, T.; Li, D.; Li, M.; Liang, D.; Diao, X.; Deng, C.; Chen, S.; Xie, Y.; Chen, D.; Zuo, D. Anti-hyperuricemic effect of 2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid in hyperuricemic mice through XOD. Molecules 2018, 23, 2671.

5. Liang, D.; Yong, T.（通讯作者）; Chen, S.; Xie, Y.; Chen, D.; Zhou, X.（通讯作者）; Li, D.; Li, M.; Su, L.; Zuo, D. Hypouricemic effect of 2,5-dihydroxyacetophenone, a computational screened bioactive compound from Ganoderma applanatum, on hyperuricemic mice. Int J Mol Sci 2018, 19, 1394.

6. Yong, T.; Chen, S.; Xie, Y.; Shuai, O.; Li, X.; Chen, D.; Su, J.; Jiao, C.; Liang, Y. Hypouricemic effects of extracts from Agrocybe aegerita on hyperuricemia mice and virtual prediction of bioactives by molecular docking. Front Pharmacol 2018, 9, 498.

7. Yong, T.; Chen, S.; Xie, Y.; Chen, D.; Su, J.; Shuai, O.; Hu, H.; Zuo, D.; Liang, D. Hypouricemic effects of Armillaria mellea on hyperuricemic mice regulated through OAT1 and CNT2. Am J Chinese Med 2018, 46, 585-599.

8. Yong, T.; Chen, S.; Xie, Y.; Chen, D.; Su, J.; Shuai, O.; Jiao, C.; Zuo, D. Cordycepin, a characteristic bioactive constituent in Cordyceps militaris, ameliorates hyperuricemia through URAT1 in hyperuricemic mice. Front Microbiol 2018, 9, 58.

9. Yong, T.; Xie, Y.; Chen, S.; Chen, D.; Su, J.; Jiao, C.; Hu, H.; Xiao, C. Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling. J Funct Foods 2018, 40, 582-588.

10. Yong, T.; Chen, S.; Xie, Y.; Chen, D.; Su, J.; Shuai, O.; Jiao, C.; Zuo, D. Hypouricemic effects of Ganoderma applanatum in hyperuricemia mice through OAT1 and GLUT9. Front Pharmacol 2017, 8, 996.

11. Yong, T.; Zuo, D.; Chen, S.; Chen, D.; Su, J. Homology modeling and molecular docking of URAT1 with chemotherapeutic agents for hyperuricemia and gout. Bioinfo Proteom Img Anal 2017, 3, 203-209.

12. Yong, T.; Zhang, M.; Chen, D.; Shuai, O.; Chen, S.; Su, J.; Jiao, C.; Feng, D.; Xie, Y. Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine. J Ethnopharmacol 2016, 194, 403-411.

13. Yong, T; Wang, J; Mai, Y; Tang, D; Zhang, L. Allyl cyanide as a new functional additive in propylene carbonate based electrolyte for lithium ion batteries. Ionics 2013, 19: 1099-1103.

14. Yong, T; Wang, J; Mai, Y; Zhao, X; Luo, H; Zhang, L. Organosilicon compounds containing nitrile and oligo(ethylene oxide) substituents as safe electrolytes for high-voltage lithium-ion batteries. J Power Sources 2014, 254: 29-32.

15. Wang, J; Yong, T; Yang, J; Ouyang, C; Zhang, L. Organosilicon functionalized glycerol carbonates as electrolytes for lithium-ion batteries. RSC Adv 2015, 5: 17660-17666.

16. Zhang, W; Chen, X; Yong, T; Xu, N; Guan, R;Yue, L. Multiwalled carbon nanotube webs welded with Si nanoparticles as high-performance anode for lithium-ion batteries. J Alloys Compd 2016, 688: 216-224.

17. Yong, T; Zhang. L; Wang, J; Mai, Y; Yan, X; Zhao, X. Novel choline-based ionic liquids as safe electrolytes for high-voltage lithium-ion batteries. J Power Sources 2016, 328: 397-404.

18. Chen, S（共同一作）; Li, X（共同一作）; Yong, T (（共同一作）); Wang, Z; Su, J; Jiao, C; Xie, Y; Yang, BB. Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships. Oncotarget. 2017, 8: 10071-10084.

19. Chen, D; Yong, T; Yang, J; Zheng, Cha; Shuai, O; Xie, Y. Docking Studies and Biological Evaluation of a Potential b-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus. Frontiers in Pharmacology  2017, 8: 219.

20. Du, WW; Zhang, C; Yang, W; Yong, T; Awan, FM; Yang, BB. Identifying and Characterizing circRNA-Protein Interaction. Theranostics 2017, 7: 4183-4191.

21. Chen, S; Yong, T; Zhang, Y; Su, J; Jiao, C; Xie, Y. Anti-tumor and Anti-angiogenic Ergosterols from Ganoderma lucidum. Frontiers in Chemistry 2017, 5: 85.

22. Chen, D; Yang, X; Yang, J; Lai, G; Yong, T; Tang, X; Shuai, O; Zhou, G; Xie, Y; Wu, Q. Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis. Frontiers in Aging Neuroscience 2017 , 9: 403.

23. Chen, S; Yong, T; Xiao, C; Su, J; Zhang, Y; Jiao, C; Xie, Y. Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities. Journal of Functional Foods 2018, 43: 196-205.

授权专利：

1. 雍天乔，谢意珍，梁丹灵，焦春伟，树舌提取物的制备方法及其用途，2017 .11 .23，中国，专利号：ZL201711180533.2

2. 雍天乔，张命龙，谢意珍，焦春伟，一种蛹虫草水提物、制备方法及其应用，2014.11.18，中国，专利号：ZL201410660797.8

3. 张灵志，雍天乔，功能化氯化胆碱离子液体、其制备方法及其在电化学储能器件中的应用，2015.04.24，中国，专利号：ZL201210585742.6

4. 张灵志，汪靖伦，雍天乔，一种用作锂离子电池过充保护剂的氧化还原梭，2015.04.28，中国，专利号：ZL201510207831.0

5. Lingzhi Zhang, TianqiaoYong. Functionalized choline chloride ionic liquid, preparation method thereof and use in electrochemical energy storage device, 2015.10.22, 美国，美国专利号：US9,728,806B2

6. 张灵志，雍天乔，含氰基高介电常数有机硅电解质材料.2012.09.15，中国，专利号：ZL201010182978.6

主持项目（省部级以上）：

1. 国家自然科学基金青年基金，虫草素通过ALPK1-URAT1-NF-κB途径改善尿酸代谢机制研究，批准号31901696， 24万元，项目负责人，在研；

2. 广州市基础与应用基础研究项目，基于虫草素骨架高尿酸血症关键靶标URAT1新型抑制剂设计、合成和生物学功能研究， 20万元，项目负责人，在研。 

附件下载：