肖春

食用菌研究发展中心    副研究员

研究领域:

    食药用菌多糖降血糖功能机制研究

代表论著:

1. Chun Xiao#,Chunwei Jiao#,YizhenXie, Linhui Ye, Qianqing Li, QingpingWu*. Grifola frondosa GF5000 improves insulin resistance by modulation the composition of gut microbiota in diabetic rats.J FunctFoods, 2021, 77:104313.

2. Chun Xiao#,Qingping Wu#*, Yizhen Xie, Jianbin Tan, Yinrun Ding, LijuanBai. Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ. Food Funct,2018,9: 6496-6508. 

3. Chun Xiao#,Qingping Wu#*, Jumei Zhang, Yizhen Xie, Jianbin Tan. Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice. J Ethnopharmacol, 2017, 196: 47-57.

4. Chun Xiao#, Qingping Wu#*, Yizhen Xie, Jumei Zhang, Jianbin Tan. Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.Food Funct, 2015, 6: 3567-3575.

5. Chun Xiao#, Qingping Wu#*, Wen Cai, Jianbin Tan, Xiaobing Yang, Jumei Zhang. Hypoglycemic effect of Ganoderma lucidum polysaccharides in type 2 diabetic mice. Arch Pharm Res, 2012, 35:1793-1801.

6. Chun Xiao, Qingping Wu*, Jianbin Tan, Wen Cai, Xiaobing Yang, Jumei Zhang. Inhibitory effects on alpha-glucosidase and hypoglycemic effects of the crude polysaccharides isolated from 11 edible fungi.J Med Plants Res,2011, 5: 6963-6967.

7. 肖春,吴清平*,蔡玟,谭剑斌,黄俊明,杨小兵.灵芝粗多糖对糖尿病小鼠的降血糖作用.中国食用菌20110337-39.

8. Yinrun Ding, Chun Xiao, Qingping Wu*, Yizhen Xie. The mechanisms underlying the hypolipidaemic effects of Grifola frondosa in the liver of rats, Front Microbiol, 2016:1186.

9.清平*,肖春,杨小兵,张菊梅.()用菌多糖类物质降血糖作用及其机理研究进展.食用菌学报2009, 1680-86.

主持项目(省部级以上):

1.广东省自然科学基金项目,面上项目,灵芝多糖F31调节GK表达改善肝脏糖代谢紊乱的分子机制研究,2021-01 2023-12,已立项;

2.广东省自然科学基金博士启动灵芝活性多糖F31的一级结构解析及其调控肝脏糖异生信号转导的研究(2015A030310001,2015-082018-0810万元已结题;

3.广东省省级产业技术研究与开发计划项目,食药用菌降血糖功能新产品的研制及产业化示范,2012-08 2015-07100万,已结题。

授权专利:

1.吴清平,肖春,谢意珍,杨小兵,李森柱.Process for Preparationof a GrifolafrondosaPolysaccharides F2 and Its Hypoglycemic Activity, 2018-12-18美国,US10155822B2.

2.吴清平,肖春,杨小兵,谢意珍,李森柱.灰树花多糖F2的制备方法及其降血糖功能2016-08-17,中国,ZL201310733480.8.

3.吴清平,肖春,杨小兵,谢意珍,李森柱.灵芝多糖F31的制备方法及其降血糖功能,2013-11-13,中国,ZL201210056087.5.



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